How do you administer Fungisome?
How to use Fungisome? It comes as a fluid for IV injection, administered by infusion into the vein by a health care professional once a day. It may be administered orally for fungal infection of the intestines or as eardrops for fungal infection of the ears.
How should amphotericin B be administered?
Amphotericin B injection is usually infused (injected slowly) intravenously over a period of 2 to 6 hours once daily. Before you receive your first dose, you may receive a test dose over 20 to 30 minutes to see if you can tolerate the medication.
How do you prepare an amphotericin B injection?
Reconstitution
- Aseptically add 12 mL of Sterile Water for Injection, USP to each AmBisome vial to yield a preparation containing 4 mg amphotericin B/mL.
- Immediately after the addition of water, SHAKE THE VIAL VIGOROUSLY for 30 seconds to completely disperse the AmBisome.
Can amphotericin be given in normal saline?
– The Amphotericin B should NEVER be mixed with Normal Saline or Half Normal Saline as it will precipitate. The line that is used for Amphotericin-B should not be used for administering any other drugs.
Can amphotericin B be given orally?
Amphotericin B can be given intravenously, orally or topically. It is not absorbed at all after oral or topical administration and so this mode of delivery is simply for prophylaxis or the treatment of mucosal infection.
How is an amphotericin B infusion reaction treated?
In clinical practice, infusion-related reactions associated with amphotericin B therapy may be blunted by slowing the infusion rate but often require premedication with acetaminophen (10 to 15 mg/kg), hydrocortisone (0.5 to 1.0 mg/kg), or meperidine (0.2 to 0.5 mg/kg).
How do you dilute inj amphotericin B?
Dilute each ‘mg’ of drug with 10 ml. [1 mg/ 10 ml ] [4 – 6 hours] * dilute the reconstituted solution with 250-500 mL D5W; final concentration should not exceed 0.1 mg/mL (peripheral infusion) or 0.25 mg/mL (central infusion).
When administering amphotericin B IV what particular precaution should you need to consider?
EXERCISE CAUTION to prevent inadvertent FUNGIZONE (amphotericin b) Intravenous overdose, which can result in potentially fatal cardiac or cardiorespiratory arrest. Verify the product name and dosage if dose prescribed exceeds 1.5 mg/kg (see OVERDOSAGE and DOSAGE AND ADMINISTRATION).
How do you dissolve amphotericin B?
Amphotericin B is sparingly soluble in aqueous buffers. For maximum solubility in aqueous buffers, amphotericin Bshould first be dissolved in DMSO and then diluted with the aqueous buffer of choice. Amphotericin B has a solubility of approximately 0.5 mg/ml in a 1:1 solution of DMSO:PBS (pH 7.2) using this method.
How do you dilute amphotericin?
Dilute each ‘mg’ of drug with 10 ml. [1 mg/ 10 ml ] [4 – 6 hours] * dilute the reconstituted solution with 250-500 mL D5W; final concentration should not exceed 0.1 mg/mL (peripheral infusion) or 0.25 mg/mL (central infusion). Add 10 mL of SWFI (without a bacteriostatic agent) to each vial of amphotericin B.
Why do we give amphotericin B with dextrose?
Amphotericin B diluted in a lipid emulsion seems to be associated with a smaller number of acute adverse events and fewer cases of hypokalemia than amphotericin B diluted in 5% dextrose. Amphotericin B is considered the drug of choice for the treatment of systemic fungal infections.
Why is amphotericin B administered orally?
The existence of an effective, safe and inexpensive oral formulation of amphotericin B would have significant applications for the treatment of disseminated fungal infections and would dramatically expand access to treatment of visceral leishmaniasis by introducing a readily available highly tolerated oral formulation …
Why is amphotericin B given IV?
FUNGIZONE (amphotericin b) Intravenous is specifically intended to treat potentially life-threatening fungal infections: aspergillosis, cryptococcosis (torulosis), North American blastomycosis, systemic candidiasis, coccidioido-mycosis, histoplasmosis, zygomycosis including mucormycosis due to susceptible species of …
How do you manage an infusion reaction?
Most infusion-related reactions to taxanes can be prevented by using premedications. Use of histamine H1- and H2-receptor antagonists and corticosteroids can decrease the occurrence of infusion-related reactions to less than 10%.
Why is amphotericin B diluted in Dextrose?
What is the most common adverse reaction to amphotericin B?
The most common side effects of amphotericin B include: Loss of potassium. Loss of magnesium. Anaphylaxis.
What are the nursing implications of amphotericin B?
Nursing considerations Ensure patient is adequately hydrated before and during therapy. Observe for adverse effects during the first 30 minutes of administration – especially for cardiotoxicity. Monitor and document vital signs including blood pressure and fluid balance.
Is amphotericin B soluble in water?
While amphotericin B is insoluble in water at pH 6-7, it is soluble at pH 2 or pH 11 at about 0.1 mg/ml. Water solubility is increased by sodium desoxycholate. It is soluble in DMF 2-4 mg/ml, in DMF + HCl up to 60-80 mg/ml, and in DMSO up to 30-40 mg/ml.
How do you give an AmBisome IV?
AmBisome should be administered by intravenous infusion over a 30 – 60 minute period. For doses greater than 5mg/kg/day, intravenous infusion over a 2 hour period is recommended (see section 4.4). The recommended concentration for intravenous infusion is 0.20 mg/ml to 2.00 mg/ml amphotericin B as AmBisome.