Do antiepileptic drugs cause cognitive impairment?
Antiepileptic drugs (AEDs) can adversely affect cognitive function by suppressing neuronal excitability or enhancing inhibitory neurotransmission. The main cognitive effects of AEDs are impaired attention, vigilance, and psychomotor speed, but secondary effects can manifest on other cognitive functions.
Does Lamictal cause memory issues?
Lamotrigine has a good cognitive profile. It does not cause a lot of memory-related side effects. In some cases, it leads to difficulty reading words. A very rare side effect of taking Lamotrigine could be memory loss.
Does lamotrigine affect cognition?
Conclusions: Lamotrigine produces significantly fewer untoward cognitive and behavioral effects compared to topiramate (TPM) at the dosages, titrations, and timeframes employed in this study. The dosages employed may not have been equivalent in efficacy.
Which antiepileptic drug is most commonly associated with significant cognitive impairment and depression?
Carbamazepine. A number of cognitive and psychomotor effects have been linked to carbamazepine [Gillham et al. 1988]. A double-blind trial reported deterioration in measures of information processing speed and attention [Wesnes et al.
Which anticonvulsants are relatively free of adverse cognitive effects?
Maximal cognitive deficits are seen with phenytoin, while phenobarbital and sodium valproate induce moderate disturbances, and carbamazepine seems relatively free from such toxicity.
Can Depakote cause cognitive issues?
Divalproex treatment was associated with accelerated brain volume loss over 1 year and perhaps with greater cognitive impairment. The long-term clinical effects of these changes are not known.
Can Lamictal affect concentration?
Since starting Lamictal almost two years ago, I have noticed some fluctuations with my mood as well as my ability to concentrate, that showed mostly as I got up in the dosage. I started at 25mg like most patients and eased my way up to my current 250mg BID (twice a day) dosage.
Does Lamictal help cognition?
There appears to be significant improvement in cognitive abilities in PBD patients treated with lamotrigine that is most prominent in the areas of working memory and verbal memory and that occurs along with mood stabilization.
Does lamotrigine affect concentration?
Lamotrigine, levetiracetam, rufinamide, and gabapentin appear to have a rather minor effect on cognitive performance – Lamotrigine is said to even improve concentration disorders in children [8, 15]. Topiramate and zonisamide, however, can also have a negative effect on cognitive performance in children.
Does Depakote affect cognitive function?
Does phenytoin cause cognitive impairment?
Phenytoin (PHT) is one of the extensively used low-cost antiepileptic drugs (AED) which is recognized to cause cognitive impairment.
What medications can cause cognitive problems?
Psychoactive drugs, antidepressants and anticonvulsants can cause dementia and delirium. In addition, non-psychoactive drugs such as histamine H2 receptor antagonists, corticosteroids, NSAIDs (nonsteroidal anti-inflammatory agent), and cardiac medications, may cause acute or chronic cognitive impairment.
Does gabapentin cause cognitive decline?
Gabapentin therapy is associated with a tangible decline in memory, executive function, and attention in individuals with spinal cord injury.
What medication causes memory problems?
A number of prescription and over-the-counter medications can interfere with or cause loss of memory. Possible culprits include: antidepressants, antihistamines, anti-anxiety medications, muscle relaxants, tranquilizers, sleeping pills, and pain medications given after surgery.
Does Lamictal cause cognitive decline?
Conclusion: Treatment with lamotrigine as monotherapy and as adjunctive therapy was associated with improved cognitive functioning and reduced neurocognitive side effects, regardless of index mood polarity.
Does Lamictal change your brain?
The antidepressant effects of lamotrigine may be linked to volumetric changes in brain regions involved in mood and emotional regulation.
Does Lamictal cause confusion?
Patients who experience headache, fever, chills, nausea, vomiting, stiff neck, rash, abnormal sensitivity to light, drowsiness, or confusion while taking Lamictal should contact their healthcare professional right away.
Can lamotrigine cause mental health problems?
Lamotrigine is generally well tolerated; however, some psychiatric problems have been reported in patients using the drug to treat mental disorders (mainly bipolar) or epilepsy. The clinical features of these psychiatric side effects are: affective switches, full acute psychotic episodes, and hallucinations.
Are there any treatments for cognitive impairment in multiple sclerosis?
Are there any treatments for cognitive impairment in multiple sclerosis? Two of the standard FDA-approved medications for MS ( Avonex ® and Betaseron ®) have been shown to slow a worsening in cognition in MS compared with placebo. One medication used in MS treatment improved measures of cognitive compared with placebo ( natalizumab ).
What are the new antiepileptic drugs?
Indications for the new antiepileptic drugs Drugs Focal seizure Generalized seizure Epileptic spasms Induced aggravation of seizure type/epilepsy syndrome Primary GTC Absence Myoclonic Lennox-Gastaut Gabapentin ABS, MCS, LGS Topiramate Lamotrigine MCS, JME, LGS, BECTS, Dravet syndrome Levetiracetam ABS Rufinamide Little information Vigabatrin
What are first-line antiepileptic drugs (AEDs) for epilepsy?
Epilepsy is one of the most common neurological diseases; its first-line treatment is the administration of antiepileptic drugs (AEDs). These are divided into first-, second-, and third-generation AEDs.
During an evaluation for cognitive problems, the patient’s medications should be checked to see if they could be interfering with cognition. The following medications may affect thinking: Steroid medications. Muscle relaxants. Some antidepressants. Major tranquilizers. Some seizure medications (e.g., topiramate)