Can I take B12 if I have MTHFR?
Management of MTHFR should be a plan tailored to your specific needs determined by you and your doctor. On a basic level, you can supplement with B12 and methylfolate. Most people who have MTHFR benefit from taking methylcobalamin (methylated B12).
How does MTHFR affect B12?
Consume more folate and vitamin B12. Those with an MTHFR mutation are also at higher risk of being low in Vitamin B12 . Vitamin B12 can be supplemented easily without a prescription, whether as isolated B12 or present in multivitamins and B complex vitamins.
Can MTHFR cause high B12?
With the inherited MTHFR mutation, it is safe to maintain optimal levels of vitamin B12 rather than the lower ones. However, elevated levels of vitamin B12 and slight leukopenia associated with neutropenia should prompt further testing to exclude myelodysplastic syndrome.
How can I help COMT mutation?
1. Because COMT is a methylation gene, it’s essential to get adequate B vitamins to support COMT, especially B2, B6, B9, and B12 as well as magnesium. To support COMT methylation, others suggest people with COMT Met/Met also take SAMe.
Can autoimmune cause high B12?
Abnormally elevated B12 has been attributed many causes [5,6], e.g., myeloid blood malignancies [7,8,9], acute or chronic liver diseases [10,11,12], chronic kidney failure, autoimmune or inflammatory diseases [3], and Gaucher disease [13].
Can MTHFR cause low B12?
For instance, mutations and polymorphisms in transport proteins such as transcobalamin TCN, gastric intrinsic factor GIF and metabolic enzymes such as methylenetetrahydrofolate reductase MTHFR have been associated with vitamin B12 deficiency.
What causes falsely elevated B12 levels?
Such falsely high valued of serum vitamin B12 levels are observed in myeloproliferative disease, acute hepatitis, severe alcoholic liver disease, and cirrhosis. Vitamin B12 binds with transcobalamin (TC) II.
Why is my vitamin B12 over 2000?
The most common cause of high B12 in the blood is due to recent ingestion or injection of supplemental vitamin B12. We don’t worry about overdosing on B12 supplements because excess can be excreted in your urine. It could also be possibly from your diet if high in animal products such as meat, eggs, and shellfish.
How do you treat low COMT activity?
Treating lower levels of COMT: Adequate B6, B12, folate and betaine to support formation of S-adenosylmethionine and prevent elevated homocysteine; S-adenosylhomocysteine inhibits COMT activity. DIM if you have high estrogens because estrogens inhibit COMT.
What causes extremely high B12 levels?
Usually, excess vitamin B12 is removed in the urine. Conditions that can increase B12 level include: Liver disease (such as cirrhosis or hepatitis) Myeloproliferative disorders (for example, polycythemia vera and chronic myelogenous leukemia)
How do you fix Overmethylation?
Correct your nutrition and supplement for over-methylation
- Folic acid. Evidence shows that folic acid supplementation improves methylation.
- Vitamin C.
- Vitamin B6 (in the form of P5P)
- Vitamin B3.
- Vitamin B12.
- Vitamin E.
- Zinc.
Does B12 need to be methylated?
While folate, vitamin B12, and betaine are essential for methylation, they are not the only nutrients needed.