Is NLRP3 a gene?
The NLRP3 gene provides instructions for making a protein called cryopyrin. Cryopyrin is a member of a family of proteins called intracellular “NOD-like” receptor (NLR) proteins. Cryopyrin is found mainly in white blood cells and in cartilage-forming cells (chondrocytes).
What does NLRP3 recognize?
NLRP3 can be activated by a wide range of stimuli following this priming step, including ATP, K+ ionophores [48], heme [49,50], particulate matter [51,52,53], pathogen-associated RNA [54,55,56,57], and bacterial and fungal toxins and components [58,59,60,61,62,63].
What is NLRP3?
NLRP3 (NOD-, LRR- and pyrin domain-containing protein 3) is an intracellular sensor that detects a broad range of microbial motifs, endogenous danger signals and environmental irritants, resulting in the formation and activation of the NLRP3 inflammasome.
Is NALP3 the same as NLRP3?
The NALP3 inflammasome is a multiprotein complex formed by the cytoplasmic pattern-recognition receptor NALP3 (also known as cryopyrin or NLRP3), the adaptor protein ASC (apoptosis-associated speck-like protein containing a carboxy-terminal CARD domain), and caspase-1.
What is the primary function of the NLRP3 inflammasome?
The primary function of the NLRP3 inflammasome is to mediate the activation of caspase-1 and the secretion of proinflammatory cytokines IL-1β/IL-18 in response to microbial infection and cellular damage.
Where is NLRP3 inflammasome located?
mitochondria 27
Similarly, Yang et al. have demonstrated that the activated NLRP3 inflammasome is located on the mitochondria 27. Conversely, Wang et al.
What does the NLRP3 gene do?
The NLRP3 gene (also known as CIAS1) provides instructions for making a protein called cryopyrin. Cryopyrin is a member of a family of proteins called nucleotide-binding domain and leucine-rich repeat containing (NLR) proteins, which are found in the fluid inside cells (cytoplasm).
What is NALP3?
NALP3 is expressed predominantly in macrophages and as a component of the inflammasome, detects products of damaged cells such as extracellular ATP and crystalline uric acid. Activated NALP3 in turn triggers an immune response. Mutations in the NLRP3 gene are associated with a number of organ specific autoimmune diseases .
What are the NACHT LRR and PYD domains-containing protein 3?
The NACHT, LRR and PYD domains-containing protein 3 is also called: PYRIN-containing APAF1-like protein 1 (PYPAF1). This gene encodes a pyrin-like protein which contains a pyrin domain, a nucleotide-binding site (NBS) domain, and a leucine-rich repeat (LRR) motif.
Is the NLRP3 inflammasome a potential drug target?
The NLRP3 inflammasome has garnered attention as a potential drug target for a variety of diseases underpinned by inflammation. The diarylsulfonylurea MCC-950 has been identified as a potent and selective NLRP3 inhibitor. Nodthera and Inflazome, have entered phase I clinical trials with NLRP3 inhibitors.