What does TTF-1 mean in lung cancer?
Thyroid transcription factor-1 (TTF-1) is a sensitive marker for pulmonary and thyroid adenocarcinomas. The aim of this work was to determine its usefulness in distinction between primary and metastatic lung adenocarcinomas.
Is mucinous adenocarcinoma a cancer?
Introduction. Mucinous adenocarcinomas (MACs) are a group of malignant tumors that originate from epithelial tissue and are characterized by abnormal mucus secretion.
Is mucinous adenocarcinoma lung cancer?
Mucinous adenocarcinoma is an unusual histological type of lung cancer, and its clinicopathological feature is distinctive from that of other histopathological types of lung adenocarcinoma. Mucinous adenocarcinoma has a mucus-producing function, which explains its name.
What is the treatment for mucinous adenocarcinoma of the lung?
Surgery is the preferred treatment option for IMA patients, except for patients with stage IIIB and IV (49). Lobectomy with lymphadenectomy is considered the standard treatment, while sublobar resection could be performed for early-stage lung cancers or for patients with low pulmonary function.
What are TTF-1 cells?
Thyroid transcription factor 1 (TTF-1) is a homeodomain-containing nuclear transcription factor which belongs to the Nkx2 gene family; it is expressed in the forebrain, thyroid and lung. TTF-1 plays a key role in morphogenesis of the lungs[1] and is expressed in up to 90% of pulmonary small cell carcinoma[2].
How common is TTF-1 in non-pulmonary adenocarcinoma lung cancer?
Results:None of the 106 non-pulmonary adenocarcinomas expressed TTF-1 and only three of the 37 non-adenocarcinoma lung cancers, all neuroendocrine carcinomas, were positive. Of the pulmonary adenocarcinomas, 75% were strongly positive for TTF-1. Mucinous (two of six) and poorly differentiated adenocarcinomas (four of 10) were less likely to stain.
Is thyroid transcription factor-1 a useful marker for lung adenocarcinomas?
Thyroid transcription factor-1 (TTF-1) is a sensitive marker for pulmonary and thyroid adenocarcinomas. The aim of this work was to determine its usefulness in distinction between primary and metastatic lung adenocarcinomas. We have examined the expression of TTF-1 in 100 solitary pulmonary nodules.
Which adenocarcinomas are less likely to stain TTF-1?
Mucinous (two of six) and poorly differentiated adenocarcinomas (four of 10) were less likely to stain. Of the peripheral adenocarcinomas, 33 of 37 were positive, whereas only seven of 14 of those of bronchial origin stained strongly. Atypical adenomatous hyperplasia strongly expressed TTF-1.
What is mucinous adenocarcinoma of the lung?
Mucinous adenocarcinoma of the lung is morphologically characterized by tall columnar cells with abundant cytoplasm that contain varying amounts of mucin (6,7). Mucus secreted by cancer cells can commonly be discharged as sputum. However, if airway obstruction happens, obstructive pneumonia occurs immediately, since the mucus fails to drain (8–10).