What is zuclopenthixol used to treat?
Zuclopenthixol (brand names Cisordinol, Clopixol and others), also known as zuclopentixol, is a medication used to treat schizophrenia and other psychoses. It is classed, pharmacologically, as a typical antipsychotic. Chemically it is a thioxanthene.
Is zuclopenthixol a sedating?
Zuclopenthixol is a sedative drug. Alertness may be impaired, especially at the start of treatment, or following the consumption of alcohol; patients should be warned of this risk and advised not to drive or operate machinery until their susceptibility is known. Patients should not drive if they have blurred vision.
What are the long term effects of Clopixol?
Clopixol 200 mg Injection may cause side effects like headache, constipation, dryness of mouth, blurred vision, weight gain, stomach pain, etc. Consult your doctor if these side effects persist or worsen. This medicine may also cause sleepiness and drowsiness.
What type of antipsychotic is zuclopenthixol?
Zuclopenthixol is a first generation antipsychotic. It is also known by the trade name Clopixol, Clopixol Acuphase and Clopixol Concentrate. You can find detailed information about this drug in the official Patient Information Leaflet (PIL).
Is Clopixol safe?
What are the risks of taking zuclopenthixol with other medications?
Zuclopenthixol reduces the antihypertensive effect of guanethidine. Concomitant use of metoclopramide and piperazine with zuclopenthixol increases the risk of extrapyramidal symptoms. Increased risk of severe neurotoxicity with lithium and sibutramine. Increased anticholinergic side effects with drugs with anticholinergic properties.
What is the mechanism of action of zuclopenthixol?
Zuclopenthixol antagonises both dopamine D 1 and D 2 receptors, α 1 -adrenoceptors and 5-HT 2 receptors with a high affinity, but has no affinity for cholinergic muscarine receptors. It weakly antagonises the histamine (H 1) receptor but has no α 2 -adrenoceptor blocking activity. Evidence from in vitro work…
How much zuclopenthixol acetate do you give a psychotic patient?
In acutely psychotic and agitated inpatients, 50 – 200 mg of zuclopenthixol acetate may be given for a calming effect over the subsequent three days, with a maximum dose of 400 mg in total to be given.
Does zuclopenthixol decanoate induce sedation?
Zuclopenthixol decanoate induces a transient dose-dependent sedation. However, if the patient is switched to maintenance treatment with zuclopenthixol decanoate from oral zuclopenthixol or from i.m. zuclopenthixol acetate the sedation will be no problem.