What are the side effects of intravesical Mitomycin?
Side effects of mitomycin C into the bladder
- skin problems including a rash, dry skin, blisters and itching.
- soreness, redness and peeling on the palms and soles of your feet – this is called hand-foot syndrome or palmar plantar syndrome.
What is instillation of Mitomycin?
Mitomycin is given directly into the bladder (called intravesicular), through a catheter, and left in the bladder for 1-2 hours. The dosage and schedule is determined by your healthcare provider. This drug is blue in color and may make your urine blue-green in color. This can last up to two days after each dose.
How long is Mitomycin good for?
Conclusions: Dissolved MMC can be stored in the refrigerator for up to 3 months without significant loss of activity. Storage at room temperature is not recommended.
Is Mitomycin cytotoxic?
Drug type: Mitomycin is an anti-cancer (“antineoplastic” or “cytotoxic”) chemotherapy drug. This medication is classified as an “antitumor antibiotic.” (For more detail, see “How this drug works” section below).
Is Mitomycin cell cycle specific?
Mitomycin is classified as an antitumor antibiotic. Antitumor antibiotics are made from natural products produced by species of the soil fungus Streptomyces. These drugs act during multiple phases of the cell cycle and are considered cell-cycle specific.
What is the success rate of Mitomycin for bladder cancer?
Across the studies, PFS rate ranged from 34–75% for mitomycin C and from 47–81% for BCG (Table II). Recurrence-free survival rate was higher for mitomycin C compared with BCG (range, 37–88.3% for mitomycin C and 21–68.5% for BCG).
What happens if you touch mitomycin?
* Contact can irritate the skin and eyes. * High exposure may cause poor appetite, fever, nausea, headache, fatigue and drowsiness. * Repeated contact can cause severe eye damage. * Repeated high exposure may affect the liver, kidneys and blood cells.
Is mitomycin a Vesicant?
Mitomycin is a potent vesicant and can cause ulceration, necrosis, cellulitis, and tissue sloughing; avoid extravasation.
What happens if you touch Mitomycin?
Is Mitomycin a Vesicant?
Is there an antidote for Mitomycin?
Pyridoxine: a potential local antidote for Mitomycin-C extravasation.
Is mitomycin a vesicant?
Is mitomycin a carcinogen?
Mitomycin C Is a probable human carcinogen, classified as weight-of-evidence Group B2 under the EPA Guidelines for Carcinogen Risk Assessment (U.S. EPA, 1986a).
What are the odds of bladder cancer returning?
Recurrence rates for bladder cancer depend on the stage of the original tumor, with 5-year recurrence rates of approximately 65% in patients with non-invasive or in situ tumors and 73% in patients with slightly more advanced disease at first diagnosis.
Is Mitomycin a hazardous drug?
It is used as an intravenous anti-cancer drug. * Mitomycin C is on the Hazardous Substance List because it is cited by IARC and EPA. * This chemical is on the Special Health Hazard Substance List because it is a MUTAGEN.
How is extravasation of chemotherapy treated?
DMSO has been used with success in human anthracycline extravasation. In humans, topical DMSO was applied immediately after extravasation covering twice the area affected. This treatment was repeated twice daily for 14 days with resolution [1].
What is the antidote for Mitomycin?
Is Mitomycin a vesicant?
Is there any risk of mitomycin extravasation?
There is a small risk of mitomycin extravasation post-operatively where the drug leaks through the bladder wall causing serious tissue injury with peritoneal necrosis, fistula formation and chronic pain. Ensure patient receives patient information sheet.
Can I do a urine culture 72 hours after mitomycin treatment?
DO NOT perform urine cultures (MC&S) 72 hours after treatment, unless urgent. There is a small risk of mitomycin extravasation post-operatively where the drug leaks through the bladder wall causing serious tissue injury with peritoneal necrosis, fistula formation and chronic pain.
How is mitmitomycin absorbed in the body?
Mitomycin is minimally absorbed from the bladder into the systemic circulation. Although myelosuppression following the intravesical use of this agent may rarely occur, clinically significant drug-drug interactions are unlikely.
Should bladder irrigation be turned off when using mitomycin?
If bladder irrigation in place, turn it off but do not disconnect tubing. If not in place continuous bladder irrigation (CBI) tubing, and sodium chloride 0.9% may be set up as per urologists instructions mitomycin should remain in bladder for a 2 hour dwell time if tolerated.