What are DBA 2 mice?
The DBA/2J mouse strain is a very commonly used inbred strain. It often serves in experimental studies as a contrast to the most popular C57BL/6J strain, as their genotypes and phenotypes are opposed in a number of respects. Like the C57BL/6J, the DBA/2J has been used in a very broad range of medical research areas.
What are DBA mice?
DBA/1J mice are widely used as a model for rheumatoid arthritis: immunization with type II collagen leads to the development of severe polyarthritis mediated by an autoimmune response. DBA/1J mice show an intermediate susceptibility to developing atherosclerotic aortic lesions on an atherogenic diet.
What is inbred and outbred mice?
outbred mice. Genetically, there are two major classes of laboratory mice: inbred and outbred. Inbred mice are genetically homogeneous and there is very little variation or heterogeneity within a pure inbred strain.
What is inbred line genetics?
An inbred line is a mouse strain that has undergone at least 20 consecutive generations of brother/sister mating making the animals genetically identical at virtually every locus except for the sex chromosomes.
Where do lab mice come from?
Because of their beginnings in the mouse fancy trade, laboratory mouse strains are a genetic mix of four different subspecies: Mus musculus musculus (eastern Europe), Mus musculus domesticus (western Europe), Mus musculus castaneus (Southeast Asia) and Mus musculus molossinus (Japan).
How many lab mice are there?
How many mice and rats are used in U.S. labs? Controversial study says more than 100 million | Science | AAAS.
Are lab mice cloned?
Lab mice differ in important ways from the common house mouse (mus musculus) that humans have lived with for centuries. For one thing, lab mice are essentially genetic clones of each other—the product of generations of careful inbreeding.
What is an outbred stock?
Definition. Stocks that are genetically undefined; that is, no two individuals from an outbred stock are the same. Outbreds are intentionally not bred with siblings or close relatives, as the purpose of an outbred stock is to maintain maximum heterozygosity. See also: Inbred Strain.
What color will the cloned mouse be?
brown
The Mouse Pup will resemble the Somatic Cell Donor, since this Donor provided the DNA for the cloned egg. The Mouse Pup will be brown (and female) like the Somatic Cell Donor.
What are outbred mice used for?
So, what can you do with Diversity Outbred mice? Since the development of these mice in 2012, they have been used for research applications including pharmacology and toxicology, oncology, type II diabetes, infectious diseases, behavioral research, and more.
Who invented the DBA/2 mouse?
DBA/2 Mouse | Charles River Laboratories. Developed by C.C. Little in 1909 from stock segregating for coat color. Oldest of all the inbred strains of mice.
What is the DBA/2 mouse model of epilepsy?
The DBA/2 mice are a long-studied model used in epilepsy research. AGS in DBA/2 mice is most widely studied, but these mice also exhibit a genetically based elevated susceptibility to absence seizures and handling-induced seizures.
What happened to the original DBA mice?
DBA mice were nearly lost in 1918, when the main stocks were wiped out by murine paratyphoid, and only three un-pedigreed mice remained alive.
What is the pathophysiology of DBA/2J inbred mice?
Young DBA/2J inbred mice are also susceptible to audiogenic seizures due to the asp2 mutation, however, this susceptibility decreases as animals reach adulthood. There is high incidence of calcareous pericarditis, and calcified lesions of the testes, tongue and skeletal muscle.