What does osteocalcin do in bone?
What is Osteocalcin? Osteocalcin is an important protein that is important for strong bones. It also acts as a hormone to adjust insulin and glucose levels, increase testosterone, and improve muscle strength and cognitive function.
Is osteocalcin a bone marker?
Osteocalcin is a bone matrix protein, which is specific for bone metabolism and it is not influenced by metabolic bone disorders. Osteocalcin is an important marker of bone turnover in physiological and pathological conditions.
How osteocalcin is regulated in bone matrix?
Osteocalcin is produced by osteoblasts as a pro-peptide that is cleaved before its secretion to remove an endoplasmic reticulum signal sequence and the pro-sequence [38]. In the circulation its concentration is ng/mL and its levels are regulated by a circadian rhythm.
What stimulates osteocalcin production?
In response to insulin, undercarboxylated osteocalcin is produced by the osteoblast or released from the bone matrix by the low pH of the osteoclast resorption pit and enters the circulation where it acts as a hormone.
Does osteocalcin bind calcium?
Osteocalcin is secreted solely by osteoblasts and thought to play a role in the body’s metabolic regulation. In its carboxylated form it binds calcium directly and thus concentrates in bone.
Where does osteocalcin come from?
Importantly, osteocalcin is secreted solely by osteoblasts but only has minor effects on bone mineralization and density. Instead, it has been reported to control several physiological processes in an endocrine manner, such as glucose homeostasis and exercise capacity, brain development, cognition, and male fertility.
Why is osteocalcin high in osteoporosis?
The deficiencies of calcium and phosphorus in osteoporotic women lower the formation of the hydroxyapatite crystals, which make the free osteocalcin to circulate in the blood. This may explain the increased concentrations of osteocalcin in the sera of osteoporotic post menopausal women [8].
What does osteocalcin bind?
The hepatic Gla proteins that function in blood coagulation bind to calcium-linked phospholipids whereas osteocalcin binds to calcium ions in hydroxyapatite (21).
What stimulates the production of osteocalcin?
Considered together, the studies by Fulzele (9) and Ferron (46) suggest that insulin regulates the production of osteocalcin and also promotes its bio-availability by favoring decarboxylation. The transcriptional mechanism through which insulin stimulates osteocalcin production has alsi been investigated.
What if osteocalcin is low?
Low osteocalcin levels usually indicate lower bone turnover. Causes shown below are commonly associated with low osteocalcin levels. Work with your doctor or another health care professional to get an accurate diagnosis.
Where is osteocalcin found?
bone
Osteocalcin, also known as bone gamma-carboxyglutamic acid-containing protein (BGLAP), is a small (49-amino-acid) noncollagenous protein hormone found in bone and dentin, first identified as a calcium-binding protein in chick bone.
What is the osteocalcin test?
Osteocalcin is a protein that helps build and maintain bones. Read on to learn more about the osteocalcin test, normal levels, what low and high osteocalcin levels mean, and what you can do to improve your bone health. The osteocalcin test measures the amount of osteocalcin in your blood. Osteocalcin is a protein hormone produced in the bones.
What are the results of high serum osteocalcin?
Bone turnover and osteoporosis are results of high serum osteocalcin. Osteocalcin blood test is required to measure the level of serum osteocalcin in the body. Blood sample is collected for osteocalcin blood test. A band is wrapped around the arm, 3-4 inches above the site of collection.
What does osteocalcin do to your body?
It binds calcium and helps build and heal bones. Osteocalcin may also help adjust insulin production and blood sugar levels, stimulate testosterone production, and improve muscle strength and brain health [ 1, 2, 3, 4, 5 ]. Osteocalcin blood levels reflect the rate of bone turnover.
How should I prepare for an osteocalcin test?
Your doctor may also order the osteocalcin test to monitor how well bone-building therapy is working. You shouldn’t take supplements containing biotin or vitamin B7 at least 12 hours before the test. Otherwise, you don’t need to prepare for the test in any special way.