What is melt granulation technique?
Melt granulation technique is a process by which pharmaceutical powders are efficiently agglomerated by a meltable binder. The advantage of this technique compared to a conventional granulation is that no water or organic solvents is needed.
What are different granulation methods for tablet formulation?
Granulation technologies like roller compaction, spray drying, supercritical fluid, low/high shear mixing, fluid bed granulation, extrusion/spheronization, etc. have been successful for many decades in the preparation of various pharmaceutical dosage forms.
Which tablet granulation method eliminates the need for a wet binder?
Advantages of dry Granulation: The main advantages of dry granulation or slugging are that it uses less equipments and space. It eliminates the need for binder solution, heavy mixing equipment and the costly and time consuming drying step required for wet granulation.
How do I make my tablet dissolve faster?
We can conclude with 95% confidence that tablets dissolve 60.61 to 66.60 seconds faster in hot water than in cold water.
What is freeze granulation?
Freeze granulation is an industrial process of producing spherical granules with excellent fluidity by spraying a liquid material under ultra-low temperature environment. The sprayed raw material instantaneously gets frozen and dried granules are obtained after sublimation (freeze drying) process.
What is fluid bed granulation?
The fluid bed granulation process (also known as agglomeration) involves suspending particles in an air stream and spraying a liquid from the top of the system down onto the fluidized bed (top-down spray). Particles in the path of the spray get slightly wet and become sticky.
What are the different techniques of granulation?
Granulation process can be divided into two types: wet granulation that utilize a liquid in the process and dry granulation that requires no liquid. The type of process selection requires thorough knowledge of physicochemical properties of the drug, excipients, required flow and release properties, to name a few.
What is slugging in granulation?
Slugging is a pre-compression process for the formation of extra large tablets (slugs), usually of variable weight, due to poor flow of the drug powder. The resulting slugs are subsequently broken down into granules, which are recompressed to obtain the final tablets.
What is the principle of granulation?
Granulation is a process in which powder particles are made to adhere to each other, resulting in larger, multi-particle entities, so called granules. If such a process is performed without adding liquids, this is called dry granulation.
Why is slugging done in tablet?
Which drug is suitable for slugging?
Objective – Slugging is a pre-compression technique for the dry granulation of hydrolysable drugs (e.g. aspirin).
How do you turn a pill into a liquid with a syringe?
Drop medication into the syringe, then crush the medication by twisting the plunger into the syringe. Liquid can then be added and the syringe shaken to mix the medication with the liquid. The dissolved medication can be administered orally or through a tube.
Can we dissolve tablets in water?
Tablets: You can dissolve some tablets in liquids like water before taking them. And if you prefer, some medications can be cut in half along a scored line to make them smaller and easier to take.
How can I make my pills more potent?
How to Make Medicines More Effective
- Always Have a Medication Guide. You can never tell when an emergency happens.
- Let Your Physician Know.
- Know Your Medicine’s Side and Adverse Effects.
- Always Take Medicines with Water.