What is telaprevir used for?
Telaprevir is used along with two other medications (ribavirin [Copegus, Rebetol] and peginterferon alfa [Pegasys]) to treat chronic hepatitis C (an ongoing viral infection that damages the liver) in people who have not yet been treated for this condition or whose condition could not successfully be treated with …
What can be treated with boceprevir?
Descriptions. Boceprevir is used in combination with injectable peginterferon alfa (Pegasys®, Pegintron®) and ribavirin (Copegus®, Rebetol®) to treat chronic hepatitis C infection.
Is telaprevir discontinued?
Vertex pharmaceuticals discontinued the sales and distribution of telaprevir in the United States in October 2014, primarily due to available alternative treatments and diminishing market demands. The drug telaprevir was formerly known as VX-950 and was co-developed by Vertex Pharmaceuticals and Johnson & Johnson.
How is boceprevir administered?
Boceprevir is administered as four pills three times daily, started after a 4-week lead-in of Peg-IFN+RBV. The duration of treatment is determined by IFN-experience, on-treatment response and cirrhosis status.
How does protease enzyme work?
Proteolytic enzymes (proteases) are enzymes that break down protein. These enzymes are made by animals, plants, fungi, and bacteria. Proteolytic enzymes break down proteins in the body or on the skin. This might help with digestion or with the breakdown of proteins involved in swelling and pain.
How do protease inhibitors inhibit viral replication?
Medications that inhibit the cleavage of the polyprotein into functional proteins are called protease inhibitors. Protease is a protein-based enzyme that normally breaks the polyprotein into functional proteins, so blocking, or inhibiting, protease prevents this essential step of viral reproduction.
What is the mechanism of protease inhibitors?
Protease inhibitor drugs block the action of protease enzymes. This prevents protease enzymes from doing their part in allowing HIV to multiply, interrupting the HIV life cycle as a result. This can stop the virus from multiplying.
What are protease inhibitors and how do they work?
Protease inhibitors are medications that help slow the progression of HIV. They do this by blocking the enzyme “protease,” which HIV cells need to develop and mature. Blocking protease prevents the virus from making copies of itself. Protease inhibitors are a type of antiretroviral therapy (ART) medication.
What is the mechanism of action of oseltamivir?
The proposed mechanism of action of oseltamivir is via inhibition of influenza virus neuraminidase with the possibility of alteration of virus particle aggregation and release.