What does IRF3 do?
IFN regulatory factor 3 (IRF3) is a transcription regulator of cellular responses in many cell types that is known to be essential for innate immunity.
What does IRF3 stand for?
Interferon regulatory factor 3
Interferon regulatory factor 3, also known as IRF3, is an interferon regulatory factor.
What is IRF immune system?
The Interferon regulatory factors (IRFs) are a family of transcription factors that play pivotal roles in many aspects of the immune response, including immune cell development and differentiation and regulating responses to pathogens.
What activates IRF7?
IRF7 is activated by pathogenic nuclei acids through pathways mediated by TLR3, -7 and -9, RIG-I and likely DNA-dependent activator of IRF and IFI16, as well as by TLR2-mediated signaling pathway.
Is IRF3 an ISG?
Viral infection activates interferon regulatory factor 3 (IRF3), a cofactor for the induction of interferon-stimulated genes (ISGs).
Is irf7 an ISG?
While IRF-3 is constitutively expressed in many tissues, IRF-7 is an ISG required for the expression of most IFN-α subtypes, and thus a key mediator of the type I IFN amplification loop [2], [9], [10].
What is IRF7 gene?
IRF7 (Interferon Regulatory Factor 7) is a Protein Coding gene. Diseases associated with IRF7 include Immunodeficiency 39 and Predisposition To Severe Viral Infection Due To Irf7 Deficiency. Among its related pathways are Cytosolic sensors of pathogen-associated DNA and Diseases of Immune System.
Is IRF7 an ISG?
What do type I interferons do?
Type I interferons (IFN-I) have long been heralded as key contributors to effective antiviral responses. More widely understood in the context of acute viral infection, the role of this pleiotropic cytokine has been characterized as triggering antiviral states in cells and potentiating adaptive immune responses.
Is Chemo an interferon?
Interferon-alfa2b is different than a chemotherapy drug; it is actually a natural part of your body’s immune system. It is known as a cytokine, which are chemicals normally secreted by cells called leukocytes in response to a virus, bacteria, or other foreign intruders.
What does IRF3 mean?
IRF3 (Interferon Regulatory Factor 3) is a Protein Coding gene. Diseases associated with IRF3 include Encephalopathy, Acute, Infection-Induced 7 and Herpes Simplex Encephalitis. Among its related pathways are Transport of the SLBP independent Mature mRNA and RIG-I/MDA5 mediated induction of IFN-alpha/beta pathways.
What is interferon regulatory factor 3 (IRF3)?
Interferon regulatory factor 3, also known as IRF3, is an interferon regulatory factor. IRF3 is a member of the interferon regulatory transcription factor (IRF) family. IRF3 was originally discovered as a homolog of IRF1 and IRF2.
What is the role of IRF3 in TLR3-mediated IFN-β gene transcription?
IRF-3 has an essential role in the TLR3-mediated IFN-β gene transcription. IRF-3 is expressed ubiquitously as an inactive monomer in the cytosol.
How is IRF3 activated in HSE?
IRF3 is normally activated by TBK1 and/or IKKε kinases. A missense IRF3 mutation has been identified in a 15-year-old patient with HSE.9 The resulting mutant IRF3 protein could not activate transcription and was dominant through haploinsufficiency.