What is rimonabant used for?
Rimonabant is an anorectic anti-obesity drug produced and marketed by Sanofi-Aventis. It is an inverse agonist for the cannabinoid receptor CB1. Its main avenue of effect is reduction in appetite. Rimonabant is the first selective CB1 receptor blocker to be approved for use anywhere in the world.
Why was Rimonabant withdrawal from the market?
Abstract. The anti-obesity medication rimonabant, an antagonist of cannabinoid type-1 (CB1) receptor, was withdrawn from the market because of adverse psychiatric side effects, including a negative affective state.
Is rimonabant a cannabinoid?
Rimonabant is a potent and selective cannabinoid CB1 receptor antagonist widely used in animal and clinical studies.
Is Rimonabant FDA approved?
Although available in Europe since 2006 for use as an adjunct to diet and exercise for obese or overweight patients with associated risk factors, Acomplia failed to secure FDA approval in the US.
How does sibutramine make you lose weight?
Sibutramine is an anti-obesity drug that produces short-term and modest body weight reductions mainly due to its appetite-suppressing effect. Despite being a useful drug in obesity treatment, awareness about the loss of effectiveness and detrimental side effects of sibutramine has recently emerged.
Who made rimonabant?
Rimonabant is a first-in-class cannabinoid type 1 (CB1) receptor blocker discovered and developed by sanofi-aventis.
Is sibutramine safe for weight loss?
Sibutramine is safe and effective for weight loss in obese patients whose hypertension is well controlled with angiotensin-converting enzyme inhibitors. J Hum Hypertens.
Does nabilone increase appetite?
Nabilone is typically used to treat severe nausea and vomiting associated with certain types of cancer chemotherapy and can be used to stimulate appetite. Nabilone is also used to treat chronic nerve related pain.
How long does it take for nabilone to kick in?
The onset of pain relief may be as soon as 1 week, although it may take a few weeks before some individuals notice pain relief. With each nabilone dose, the onset of effect is within 60–90 minutes, and the duration of action is 8–12 hours.
How much weight can you lose on rimonabant?
Evidence review: There is clear evidence that rimonabant 20 mg/day in conjunction with a hypocaloric diet causes a mean weight loss of 4.6 kg in obese and overweight patients after 1 year’s treatment, with approximately 50% of patients achieving a weight loss of ≥5%. One study demonstrated that weight loss is maintained for up to 2 years.
Is rimonabant effective in the treatment of obesity and overweight patients?
Rimonabant (SR-141716A; Acomplia®, Sanofi-Aventis) is a novel CB1 antagonist. This article reviews the evidence of the effectiveness of rimonabant in the treatment of obese or overweight patients, including those with additional cardiovascular risk factors associated with metabolic syndrome.
What are the possible adverse effects of rimonabant?
The effect of rimonabant appears to be partly independent of weight loss. Rimonabant 20 mg/day is generally well tolerated, with mild to moderate transient adverse effects including nausea, diarrhea, dizziness, and anxiety.
Rimonabant is a novel compound which has been shown to block endocannabinoid CB1 receptors, reduce food intake, and promote weight loss in animal and human studies (Kirkham & Williams 2001; Williams & Kirkham 2002; Fernandez & Allison 2004; Jbilo et al. 2005; Poirier et al. 2005).