What is the route of administration of cyclophosphamide?
It is usually given through a vein by injection or infusion (intravenous, IV) or by mouth in tablet form, depending upon diagnosis. Cyclophosphamide is also approved to be given by a shot into a muscle (IM), into the abdominal lining (intraperitoneal, IP), or into the lining of the lung (intrapleural).
What are the contraindications of cyclophosphamide?
Who should not take CYCLOPHOSPHAMIDE?
- a bacterial infection.
- chickenpox.
- shingles.
- opportunistic fungal infection.
- an infection due to a protozoa organism.
- an infection due to a parasite.
- myeloproliferative neoplasm.
- low amount of sodium in the blood.
Which drug is incompatible with PVC giving sets?
Abstract: Diazepam is highly sorbed to the plastic materials of administration sets for intravenous infusion. This can be detrimental as it should be delivered to the patient at the administered amount for efficacy and safety.
What drugs interact with cyclophosphamide?
Some products that may interact with this drug include: allopurinol, chloramphenicol, chloroquine, digoxin, phenobarbital, phenothiazines, primidone, St John’s wort, turmeric (curcumin), voclosporin.
What IV drugs are incompatible?
Type of intravenous drug administration involved in incompatibilities….Table 2.
Drug incompatibilities | N (%) |
---|---|
Hydrocortisone x midazolam | 24 (8.9) |
Cefepime x midazolam | 14 (5.2) |
Hydrocortisone x vancomycin | 14 (5.2) |
Cefepime x vancomycin | 12 (4.4) |
How long does cyclophosphamide infusion take?
Cyclophosphamide takes an hour to infuse, but the entire treatment is a longer process and takes five to six hours. At HSS patients are given fluid for two hours prior to receiving the medication and for two hours afterwards.
How can you minimize the adverse effects of cyclophosphamide?
Changes in diet such as eating several small meals or limiting activity may help lessen some of these effects. If these effects persist or worsen, notify your doctor or pharmacist promptly. Temporary hair loss may occur. Hair growth should return after treatment has ended or may even return during treatment.
How do I know if IV meds are compatible?
pH. Generally, to avoid incompatibility, drugs and solutions that are to be mixed should have similar pH values. The pH of each I.V. solution is listed on the manufacturer’s label, and the pH of each drug is provided in the package insert.
What IV medications are not compatible with normal saline?
IV Diazepam (valium) is incompatible with most drugs and fluids, including normal saline. When in contact with other fluids it precipitates as well.
How toxic is cyclophosphamide?
Long-term use of cyclophosphamide is associated with a multitude of significant side effects, such as hair loss, leukopenia, hemorrhagic cystitis, infertility, the development of secondary malignancies, and pulmonary toxicity.
What happens if you run incompatible IV medications?
Drug incompatibility results from the simultaneous dilution and/or administration of two or more drugs that interfere with the therapeutic efficacy of the medications and patient safety, visually evidenced by change of solution color, precipitation, or turbidity.
Is Dilaudid compatible with potassium?
Interactions between your drugs No interactions were found between Dilaudid-HP and potassium chloride.
What IV meds are not compatible?
The most commonly found drug incompatibilities were between midazolam and hydrocortisone (8.9%), between cefepime and midazolam (5.2%), and between hydrocortisone and vancomycin (5.2%). The drugs most commonly involved in incompatibilities were midazolam, hydrocortisone, and vancomycin.
How many milligrams of Dilaudid can you take?
The initial starting dose is 0.2 to 1 mg every 2 to 3 hours. Intravenous administration should be given slowly, over at least 2 to 3 minutes, depending on the dose. The initial dose should be reduced in the elderly or debilitated and may be lowered to 0.2 mg. Conversion From Other Opioids to DILAUDID INJECTION or DILAUDID-HP INJECTION:
Can Dilaudid HP be given subcutaneously?
Do not use DILAUDID-HP for patients who are not tolerant to the respiratory depressant or sedating effects of opioids. Subcutaneous or Intramuscular Administration: The usual starting dose of DILAUDID INJECTION is 1 mg to 2 mg every 2 to 3 hours as necessary.
How do you administer cyclophosphamide IV?
Administration: Slow IVP (doses ≤1 gram 2): Cyclophosphamide should be prepared for parenteral use by adding 0.9% sterile sodium chloride solution if injected directly. IVPB or continuous intravenous infusion 2 : I.V. infusions may be administered over 1 to 24 hours. Doses >500 mg to approximately 2 grams may be administered over 20-30 minutes.
How is Dilaudid injection (hydromorphone hydrochloride) supplied?
16 HOW SUPPLIED/STORAGE AND HANDLING DILAUDID INJECTION (hydromorphone hydrochloride) is supplied in clear and colorless single-dose prefilled syringes. Each single-dose prefilled syringe of sterile, aqueous solution contains 0.5 mg, 1 mg or 2 mg hydromorphone hydrochloride with 0.2% sodium citrate and 0.2% citric acid solution.