What is CD123 a marker for?
Other recent studies have provided evidence that CD123 is a useful marker of leukemia-initiating cells in Fanconi anemia AML cells.
Where is CD123 expressed?
CD123 was previously reported to be expressed at a low level or to be absent on normal hematopoietic stem cells, but it is expressed at various levels in hematologic malignancies, including hairy cell leukemia,12 acute myeloid leukemia,13 blastic plasmacytoid dendritic cell neoplasm,14–16 and systemic mastocytosis.
What does CD123 stain?
D. TCF4 / CD123 dual stains are highly sensitive and specific to blastic plasmacytoid dendritic cell neoplasm. Such staining is rarely encountered in other malignancies.
What is IMGN632?
IMGN632 is a CD123-targeting ADC in clinical development for hematological malignancies, including blastic plasmacytoid dendritic cell neoplasm (BPDCN) and acute myeloid leukemia (AML).
What are CD123 cells?
CD123, the α chain of the interleukin 3 receptor, is a cytokine receptor that is overexpressed in multiple hematolymphoid neoplasms, including acute myeloid leukemia, blastic plasmacytoid dendritic cell neoplasm, acute lymphoblastic leukemia, hairy cell leukemia, and systemic mastocytosis.
Do B cells express CD123?
In conclusion, we found that CD123 expression is generally low in B-cell precursors and mature B cells both in HC BM samples and in post-chemotherapy regenerating B cells. The CD123 overexpression in B-precursor ALL correlated with hyperdiploid genotype, the second most common genetic abnormality in childhood ALL.
What is CD38 a marker of?
CD38 is a multi-functional transmembrane protein that is a lymphocyte receptor and a clinical marker for survival of patients with B-cell chronic lymphocytic leukemia (CLL) [1-5].
Is CD38 negative good?
In contrast, the CD38- negative group required minimal or no treatment, remained treatment-free for a longer time period and had prolonged survival (P < 0.05). CD38 expression was a robust marker in the majority of patients in that it was stable over time and not significantly influenced by chemotherapy.
What cells are CD34 positive?
CD34+ HPCs are isolated from human blood stem cells upon apheresis. Upon transplantation with the CD34+ HPCs, these cells can differentiate into a variety of cell types including fibroblasts, osteoblasts, chondrocytes, myocytes, adipocytes, and endothelial cells.